Original article / research
Year :
2024 |
Month :
April
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Volume :
13 |
Issue :
2 |
Page :
BO01 - BO04 |
Full Version
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Vitamin D Levels among Chronic Kidney Disease Patients at a Tertiary Care Hospital: A Cross-sectional Study
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M Sreevani, B Srinivasa Rao, S Srivanvani 1. Associate Professor, Department of Biochemistry, Siddhartha Medical College, Vijayawada, Andhra Pradesh, India.
2. Professor, Department of General Medicine, Siddhartha Medical College, Vijayawada, Andhra Pradesh, India.
3. Professor, Department of Biochemistry, Siddhartha Medical College, Vijayawada, Andhra Pradesh, India.
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Correspondence
Address :
M Sreevani, B Srinivasa Rao, S Srivanvani, M Sreevani,
H.no 11-77; Ashok Nagar, Kanuru, Krishna District, Vijayawada-520007, Andhra Pradesh, India.
E-mail: mattasreevani@yahoo.com
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| ABSTRACT | | : Introduction: In patients with Chronic Kidney Disease (CKD), a high prevalence of metabolite abnormalities has been observed. Numerous studies have demonstrated that individuals with reduced Glomerular Filtration Rate (GFR) are more susceptible to severe vitamin D deficiency compared to those with normal kidney function.
Aim: To investigate the association between vitamin D levels and the severity of CKD among patients at Siddhartha Medical College, GGH in Vijayawada, Andhra Pradesh, India.
Materials and Methods: The present hospital-based cross-sectional study was conducted at Siddhartha Medical College, GGH, Vijayawada, Andhra Pradesh, India from December 2021 to February 2022. A total of 100 CKD patients with a GFR of less than 60 mL/min/1.72 m2 were included in the study. Vitamin D levels were assessed using Chemiluminescence immunoassay (Access 2, Beckman Coulter), and vitamin D deficiency was defined as 25-OH vitamin D levels of less than 10 ng/mL, while insufficiency was defined as levels between 10 to 30 ng/mL. Statistical analysis was performed using Analysis of Variance (ANOVA) test and Pearson’s correlation test.
Results: The mean age of the study population was 53.25±7.6 years, with the majority (32%) belonging to the 51-60 years age group. In terms of gender distribution, approximately three-fourths (72%) of the subjects were male. Hypertension was present in 44% of CKD patients, diabetes in 38%, and cardiovascular disease in 38%. Total 53% of CKD patients were classified as stage 4 on the Kidney Disease: Improving Global Outcome (KDIGO) CKD staging. Vitamin D deficiency was observed in 26% of patients, while 39% had insufficiency. A statistically significant association was found between the severity of CKD staging and mean vitamin D levels, with lower mean levels observed in stages 4 and 5.
Conclusion: Vitamin D deficiency was present in one-fourth of the CKD patients, and it was more pronounced in advanced stages of CKD. |
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Keywords
: Glomerular filtration rate, Hypertension, Metabolite abnormalities, Renal disease |
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DOI and Others
: DOI: 10.7860/NJLM/2024/59460.2821
Date of Submission: Aug 02, 2023
Date of Peer Review: Sep 14, 2023
Date of Acceptance: Sep 30, 2023
Date of Publishing: Apr 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHO |
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